National Cancer Institute
U.S. National Institute of Health www.cancer.gov National Cancer Institute
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CENTERS

 
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Physical Science-Oncology Centers

The National Cancer Institute (NCI) has awarded cooperative agreements to 12 leading institutions to build a collaborative network of Physical Science-Oncology Centers (PS-OCs).
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RESEARCH HIGHLIGHTS

 
The Mathematician Versus the Malignancy
Mathematical biologists are working with clinicians to test whether sophisticated treatment schedules can improve the efficacy of existing cancer drugs.
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2014 PS-OC January Publications
Collagen networks provide mechanical signals to promote breast cancer cell invasiveness
A research group set out to better determine how mammary acini interact with collagen and whether or not these interactions cause the acini to become more invasive and cancerous.
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Cell squishiness as a biophysical marker for detecting cancer
A research group has demonstrated a new way to diagnose cancer in clinical patient samples. This new method, called deformability cytometry (DC), can measure mechanical changes in a cell population to determine if cells are cancerous.
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Additional Papers of Note for January
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2013 PS-OC Publications

A collection of publications from the PS-OC network for 2013
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MEDIA

 
Paul Davies at New Scientist Live Event in London
Hear leading cosmologist and author Paul Davies describe new insights that come from looking at cancer cells as physical objects - including a radically new approach to therapy. This New Scientist Live event took place at Conway Hall, London, on 5 June 2013. Paul Davies directs the Beyond Center for Fundamental Concepts in Science at Arizona State University.
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Tracking Ovarian Cancer Through Blood Cells
Dr. Kelly Bethel, from the Scripps PS-OC discusses how monitoring Circulating Tumor Cells (CTCs) in the blood of ovarian cancer patients is being used to monitor to track response to treatments and disease progression.
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Dr. Franziska Michor on "When does 2 + 2 = LIFE?"
Franziska Michor, PI of the Dana Farber Cancer Institute PS-OC discusses how mathematical approaches can help us understand and combat cancer at the TEDMED conference.
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Cancer in 3-D
Denis Wirtz from the Johns Hopkins University PS-OC presents his research on how 2-dimensional and 3-dimensional environments impact cancer and cell migration. Video courtesy of the Northwestern University PS-OC.
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Fundamental Mechanochemistry of Tumor Progression
Jan Liphardt of the University of California, Berkeley PS-OC discusses the research on how cell mechanics and physical forces regulate tissue architecture and cancer progression. Video courtesy of the Northwestern University PS-OC.
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Measuring a Single Cell's Density
Scott Manalis and colleagues at the Massachusetts Institute of Technology PS-OC have designed a microfluidic device to determine the mass and density of single cells. Video Courtesy of the Massachusetts Institute of Technology.
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Real-time Intravital Microscopy for Optimization of Nanotherapeutics Delivery to Tumors
Dr. Anne van de Ven of The Methodist Hospital and Research Institute PS-OC presents her work on how imaging techniques can be used to help researchers design nanoparticles to optimize the delivery of cancer therapeutics to tumors. Video courtesy of The Methodist Hospital and Research Institute PS-OC.
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The Fluid Phase of Solid Tumors: How does cancer spread?
Dr. Peter Kuhn of The Scripps Research Institute PS-OC presents his research on how cancer cells in the blood can shed light on the spread of cancer during metastasis and potentially be used to provide patients and clinicians with diagnostic and prognostic information. Video courtesy of Arizona State University PS-OC.
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Dr. Jacob Scott on "Can we stop the imaginectomies?"
Dr. Jacob Scott, of the H. Lee Moffit Cancer Center PS-OC, discusses how new perspectives and creativity is needed to help researchers find new connections to better understand and treat cancer.
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Image of Paul Davies, Ph.D.

Could physics provide the key to cancer?
Paul Davies and Roger Johnson from the Arizona State University discuss the insights and perspectives that physicists bring to cancer research with the BBC science reporter Tom Feilden.
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RESOURCES

 
PBCF Logo PS-OC Network Bioresource Core Facility (PBCF)
The PBCF provides the Network with common stocks of an authenticated set of non-malignant and cancerous cell lines, cell culture reagents, and related standard operating protocols. Investigators outside of the Network who agree to actively participate in data sharing and integration efforts can become part of the PS-OC Network and gain access to this resource.
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money Funding Opportunites
A collection of funding opportunities at the intersection of physical sciences and cancer research from the NIH, NSF, and other funding organizations. Check regularly for new updates.
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Reports
Contributions from outside the field of cancer biology are the cornerstone of the Physical Sciences in Oncology initiative. Learn more about the latest ideas from thought leaders from the fields of cancer biology, physics, chemistry, mathematics, modeling, engineering, and nanotechnology.
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